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Article Dans Une Revue Journal of Biosciences Année : 2007

Protein mechanics: a route from structure to function.

Résumé

In order to better understand the mechanical properties of proteins, we have developed simulation tools which enable these properties to be analysed on a residue-by-residue basis. Although these calculations are relatively expensive with all-atom protein models, good results can be obtained much faster using coarse-grained approaches. The results show that proteins are surprisingly heterogeneous from a mechanical point of view and that functionally important residues often exhibit unusual mechanical behaviour. This finding offers a novel means for detecting functional sites and also potentially provides a route for understanding the links between structure and function in more general terms.In order to better understand the mechanical properties of proteins, we have developed simulation tools which enable these properties to be analysed on a residue-by-residue basis. Although these calculations are relatively expensive with all-atom protein models, good results can be obtained much faster using coarse-grained approaches. The results show that proteins are surprisingly heterogeneous from a mechanical point of view and that functionally important residues often exhibit unusual mechanical behaviour. This finding offers a novel means for detecting functional sites and also potentially provides a route for understanding the links between structure and function in more general terms.
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Dates et versions

hal-00315141 , version 1 (27-08-2008)

Identifiants

  • HAL Id : hal-00315141 , version 1
  • PUBMED : 17914231

Citer

R. Lavery, S. Sacquin-Mora. Protein mechanics: a route from structure to function.. Journal of Biosciences, 2007, 32, pp.891-898. ⟨hal-00315141⟩
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