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Article Dans Une Revue Med Biol Eng Comput Année : 2000

Collagen-based biomaterials as 3D scaffold for cell cultures: applications for tissue engineering and gene therapy.

Résumé

Many substances are used in the production of biomaterials: metals (titanium), ceramics (alumina), synthetic polymers (polyurethanes, silicones, polyglycolic acid (PGA), polylactic acid (PLA), copolymers of lactic and glycolic acids (PLGA), polyanhydrides, polyorthoesters) and natural polymers (chitosan, glycosaminoglycans, collagen). With the rapid development in tissue engineering, these different biomaterials have been used as three-dimensional scaffolds and cell transplant devices. The principal biochemical and biological characteristics of the collagen-based biomaterials are presented, including their interactions with cells (fibroblasts), distinct from those of synthetic polymers, and their potential use in gene therapy through the formation of neo-organs or organoids.Many substances are used in the production of biomaterials: metals (titanium), ceramics (alumina), synthetic polymers (polyurethanes, silicones, polyglycolic acid (PGA), polylactic acid (PLA), copolymers of lactic and glycolic acids (PLGA), polyanhydrides, polyorthoesters) and natural polymers (chitosan, glycosaminoglycans, collagen). With the rapid development in tissue engineering, these different biomaterials have been used as three-dimensional scaffolds and cell transplant devices. The principal biochemical and biological characteristics of the collagen-based biomaterials are presented, including their interactions with cells (fibroblasts), distinct from those of synthetic polymers, and their potential use in gene therapy through the formation of neo-organs or organoids.
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Dates et versions

hal-00313315 , version 1 (27-08-2008)

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  • HAL Id : hal-00313315 , version 1

Citer

B. Chevallay, D. Herbage. Collagen-based biomaterials as 3D scaffold for cell cultures: applications for tissue engineering and gene therapy.. Med Biol Eng Comput, 2000, 38, pp.211-218. ⟨hal-00313315⟩
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