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Article Dans Une Revue Trends in Neurosciences Année : 2006

Intraneuronal trafficking of G-protein-coupled receptors in vivo.

Résumé

In vitro studies have widely demonstrated that the abundance and availability of G-protein-coupled receptors (GPCRs) at the cell surface is regulated by the neuronal environment and is the result of complex intraneuronal trafficking. However, this regulation is still poorly understood in vivo. Modulation of receptor availability at the neuronal membrane is a key event in the regulation of neuronal functions (e.g. neurotransmitter release or neuronal excitability in physiological, pathological or therapeutic conditions). We discuss the effects of duration of receptor stimulation (acute versus chronic) on the intraneuronal trafficking of GPCRs in vivo, and we show that this trafficking might differ according to subcellular compartment (soma, dendrites or axon terminals).

Domaines

Neurobiologie

Dates et versions

hal-00297296 , version 1 (15-07-2008)

Identifiants

Citer

Veronique Bernard, Marion Decossas, Isabel Liste, Bertrand Bloch. Intraneuronal trafficking of G-protein-coupled receptors in vivo.. Trends in Neurosciences, 2006, 29 (3), pp.140-7. ⟨10.1016/j.tins.2006.01.006⟩. ⟨hal-00297296⟩

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