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Article Dans Une Revue Bioorganic and Medicinal Chemistry Letters Année : 2008

Design, synthesis and evaluation of potent thymidylate synthase X inhibitors.

F. Esra Onen
  • Fonction : Auteur
Claire Jacquement
  • Fonction : Auteur
Maria Vittoria Spanedda
  • Fonction : Auteur
Nada Jaber
  • Fonction : Auteur
Daniel Scherman
  • Fonction : Auteur
Jean Herscovici
  • Fonction : Auteur

Résumé

Three synthesized series of compounds based on a thiazolidine core allowed identification of potent inhibitors of thymidylate synthase X. The evaluation of the catalytic activity of the enzyme in the presence of these molecules revealed two distinct classes of compounds that inhibit ThyX with submicromolar concentrations, which could lead, after optimization, to effective inhibitors with potential biomedical interest.

Dates et versions

hal-00297137 , version 1 (15-07-2008)

Identifiants

Citer

F. Esra Onen, Yap Boum, Claire Jacquement, Maria Vittoria Spanedda, Nada Jaber, et al.. Design, synthesis and evaluation of potent thymidylate synthase X inhibitors.. Bioorganic and Medicinal Chemistry Letters, 2008, 18 (12), pp.3628-31. ⟨10.1016/j.bmcl.2008.04.080⟩. ⟨hal-00297137⟩
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