Rostral ventrolateral medulla and respiratory rhythmogenesis in mice. - Archive ouverte HAL
Article Dans Une Revue Neuroscience Letters Année : 1997

Rostral ventrolateral medulla and respiratory rhythmogenesis in mice.

Résumé

To compare the mechanisms governing perinatal respiratory rhythmogenesis in mice and rats, we adapted to the neonatal mouse the in vitro brainstem-spinal cord preparation of the neonatal rat. In mouse preparations retaining the pons, phrenic root did not show any rhythmic activity. Elimination of the pons induced phrenic rhythmic bursts which (1) induced respiratory chest movements (rib cage kept attached to the spinal cord), (2) were abolished by spinal cord transection, (3) could be prematurely induced by rostral ventro-lateral medulla (RVLM) stimulation, (4) occurred in phase with the bursting firing of RVLM neurons, and (5) were abolished by RVLM lesion. Then, the RVLM appears crucial for respiratory rhythmogenesis in both species; some results suggest however that vagal and pontine respiratory controls might not be identical in mice and rats.
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Dates et versions

hal-00290872 , version 1 (26-06-2008)

Identifiants

  • HAL Id : hal-00290872 , version 1
  • PUBMED : 9132679

Citer

G. Hilaire, C. Bou, R. Monteau. Rostral ventrolateral medulla and respiratory rhythmogenesis in mice.. Neuroscience Letters, 1997, 224 (1), pp.13-6. ⟨hal-00290872⟩

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