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Article Dans Une Revue European Journal of Organic Chemistry Année : 2008

Straightforward Synthesis of Chiral Silylated Amino Acids through Hydrolysation

Résumé

A method using hydrosylation of unsaturated amino acids was developed and optimised to obtain silylated amino acids. The platinum (Bu4N)2PtCl6 complex was identfied as the best catalyst, and the procedure tolerated different unsaturated substrates, silane reagents and protecting groups. Seven silicon-containing alpha-amino acids were prepared in an enantiomerically pure form under mild conditions in good yields with orthogonal protections for versatile use in peptide synthesis.

Domaines

Chimie organique

Dates et versions

hal-00287572 , version 1 (12-06-2008)

Identifiants

Citer

Damien Marchand, Jean Martinez, Florine Cavelier. Straightforward Synthesis of Chiral Silylated Amino Acids through Hydrolysation. European Journal of Organic Chemistry, 2008, pp.3107-3112. ⟨10.1002/ejoc.200800066⟩. ⟨hal-00287572⟩
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