SICVER is the French acronym of a collaborative research project, started in October 2006, and funded by ESA, ASTRIUM Space Transportation and the Regional Council of Aquitaine (France). This project is driven by IMS-LAPS, University Bordeaux 1 and is part of the VER/VEP project, supported by the Aerospace Valley cluster. SICVER aims at developing “Innovative Fault Detection, Isolation and Reconfiguration (FDIR) Strategies for Experimental Re-entry Vehicles”. The project includes two research areas. The first one deals with the design of a fault-tolerant on-board path planner ensuring a high level of spacecraft autonomy. The goal is to help the ground-level operations and to improve decision making. The second part deals with the design of an on-board fault diagnosis system dedicated to the detection and isolation of any relevant actuator fault which may occur during an atmospheric re-entry mission and which could lead to flight performance degradations. The FDIR module acts as a supervisory layer which manages all or a part of the GNC chain during the re-entry mission in order to assign a level of operational and/or decisional autonomy to the vehicle. Such a level of autonomy can be reached first by monitoring the vehicle behaviour, then by reconfiguring all or a part of the G&C chain when a faulty scenario occurs.