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Article Dans Une Revue Angewandte Chemie International Edition Année : 2008

Detection of enzymatic activity by PARACEST MRI: a general approach to target a large variety of enzymes

Résumé

We report a new family of molecular imaging probes that offer the possibility of specific PARACEST (paramagnetic chemical exchange saturation transfer) MRI detection of a large variety of enzymatic activities. The probes are based on a lanthanide complex coupled to an enzyme-specific substrate through a self-immolative spacer. Upon enzymatic cleavage of the substrate, the spacer is spontaneously eliminated, thereby resulting in a remarkable change in the PARACEST properties of the Ln3+ chelate. This new type of contrast agent opens up new perspectives in molecular magnetic resonance imaging.

Dates et versions

hal-00283242 , version 1 (29-05-2008)

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Citer

Thomas Chauvin, Philippe Durand, Michèle Bernier, Hervé Meudal, Bich-Thuy Doan, et al.. Detection of enzymatic activity by PARACEST MRI: a general approach to target a large variety of enzymes. Angewandte Chemie International Edition, 2008, 47 (23), pp.4370-4372. ⟨10.1002/anie.200800809⟩. ⟨hal-00283242⟩
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