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Article Dans Une Revue Journal of Chromatography A Année : 2008

Separation of amino acid enantiomers via chiral derivatization and non chiral column by gas chromatography

Résumé

Two GC-MS methods for the enantioselective separation of the 20 proteinogenic amino acids are compared. Ethyl chloroformate and 2-chloropropanol were used to derivatize amino acid enantiomers. The diastereomers formed were separated on a non-chiral column by capillary gas chromatography. The separation performances were compared to those obtained when using non-chiral derivatization on a chiral column.

Dates et versions

hal-00282553 , version 1 (27-05-2008)

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Marylène Bertrand, Annie Chabin, André Brack, Frances Westall. Separation of amino acid enantiomers via chiral derivatization and non chiral column by gas chromatography. Journal of Chromatography A, 2008, 1180 (1-2), pp.131-137. ⟨10.1016/j.chroma.2007.12.004⟩. ⟨hal-00282553⟩
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