Palladium-mediated intramolecular C-N bond formation involving allyl substituted pyridines. Application to a novel strategy for the synthesis of the skeleton of berberinium derivatives - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Organometallic Chemistry Année : 2003

Palladium-mediated intramolecular C-N bond formation involving allyl substituted pyridines. Application to a novel strategy for the synthesis of the skeleton of berberinium derivatives

Résumé

The insertion of allenes in the Pd-C sigma bond of cyclopalladated pyridine derivatives afforded (eta3-allyl) Pd complexes. The ideally located imine unit reacted selectively with the allyl functionality to yield a series of new cationic heterocycles. The process opened the route to a novel strategy for the synthesis of berberiniums, a class of molecules of pharmacological interest.

Dates et versions

hal-00281229 , version 1 (21-05-2008)

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Jaganaiden Chengebroyen, Myriam Linke, Mike Robitzer, Claude Sirlin, Michel Pfeffer. Palladium-mediated intramolecular C-N bond formation involving allyl substituted pyridines. Application to a novel strategy for the synthesis of the skeleton of berberinium derivatives. Journal of Organometallic Chemistry, 2003, 687 (2), pp.313-321. ⟨10.1016/j.jorganchem.2003.06.001⟩. ⟨hal-00281229⟩

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