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Article Dans Une Revue Brain Injury Année : 2006

fMRI study of problem-solving after severe traumatic brain injury.

Résumé

OBJECTIVE: To assess the cerebral correlates of the dysexecutive syndrome after diffuse severe traumatic brain injury (TBI). METHODS: Ten patients with sub-acute/chronic severe TBI without detectable focal cortical contusion and 11 matched healthy subjects were included in a parametric fMRI study using a planning task, the Tower of London. RESULTS: Brain activation in the left Dorsolateral Pre-frontal Cortex (DLPFC) and the Anterior Cingulate Cortex (ACC) was closely related to performance. Patients with TBI who performed the task efficiently showed, like healthy controls who obtained a similar pattern of performance, a large activation in the left DLPFC and a small activation in the ACC. In contrast, poor performance was associated with a reduced activation in these both regions. CONCLUSION: Problem-solving deficits after severe diffuse TBI could be related to an impaired activation of the DLPFC and of the ACC.
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Dates et versions

hal-00272333 , version 1 (11-04-2008)

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Citer

Fabienne Cazalis, Antoine Feydy, Romain Valabrègue, Mélanie Pélégrini-Issac, Laurent Pierot, et al.. fMRI study of problem-solving after severe traumatic brain injury.. Brain Injury, 2006, 20 (10), pp.1019-28. ⟨10.1080/02699050600664384⟩. ⟨hal-00272333⟩
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