Palladium-catalyzed domino intramolecular N-arylation/intermolecular C-C bond formation for the synthesis of functionalized benzodiazepinediones. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Organic Letters Année : 2008

Palladium-catalyzed domino intramolecular N-arylation/intermolecular C-C bond formation for the synthesis of functionalized benzodiazepinediones.

Résumé

A divergent and regiocontrolled Pd-catalyzed domino sequence involving an intramolecular N-arylation and an intermolecular Heck reaction has been developed, providing rapid access to functionalized benzodiazepine-2,5-diones 3. The starting materials were synthesized by the Ugi four-component reaction. An unprecedented X-ray structure of bispalladacycle 6 was documented.
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Dates et versions

hal-00265825 , version 1 (20-03-2008)

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Angela Salcedo, Luc Neuville, Christophe Rondot, Pascal Retailleau, Jieping Zhu. Palladium-catalyzed domino intramolecular N-arylation/intermolecular C-C bond formation for the synthesis of functionalized benzodiazepinediones.. Organic Letters, 2008, 10 (5), pp.857-60. ⟨10.1021/ol7029799⟩. ⟨hal-00265825⟩
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