The Drosophila NURF remodelling and the ATAC histone acetylase complexes functionally interact and are required for global chromosome organization. - Archive ouverte HAL Access content directly
Journal Articles EMBO Reports Year : 2008

The Drosophila NURF remodelling and the ATAC histone acetylase complexes functionally interact and are required for global chromosome organization.

Abstract

Drosophila Gcn5 is the catalytic subunit of the SAGA and ATAC histone acetylase complexes. Here, we show that mutations in Gcn5 and the ATAC component Ada2a induce a decondensation of the male X chromosome, similar to that induced by mutations in the Iswi and Nurf301 subunits of the NURF nucleosome remodelling complex. Genetic studies as well as transcript profiling analysis indicate that ATAC and NURF regulate overlapping sets of target genes during development. In addition, we find that Ada2a chromosome binding and histone H4-Lys12 acetylation are compromised in Iswi and Nurf301 mutants. Our results strongly suggest that NURF is required for ATAC to access the chromatin and to regulate global chromosome organization.

Keywords

Dates and versions

hal-00261962 , version 1 (10-03-2008)

Identifiers

Cite

Clément Carré, Anita Ciurciu, Orbán Komonyi, Caroline Jacquier, Delphine Fagegaltier, et al.. The Drosophila NURF remodelling and the ATAC histone acetylase complexes functionally interact and are required for global chromosome organization.. EMBO Reports, 2008, 9 (2), pp.187-92. ⟨10.1038/sj.embor.7401141⟩. ⟨hal-00261962⟩
61 View
0 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More