Functional implication of the vitamin A signaling pathway in the brain. - Archive ouverte HAL Access content directly
Journal Articles Archives of Neurology -Chigago- Year : 2007

Functional implication of the vitamin A signaling pathway in the brain.

Abstract

Vitamin A is necessary for normal embryonic development, but its role in the adult brain is poorly understood. Vitamin A derivatives, retinoids, are involved in a complex signaling pathway that regulates gene expression and, in the central nervous system, controls neuronal differentiation and neural tube patterning. Although a major functional implication of retinoic signaling has been repeatedly suggested in synaptic plasticity, learning and memory, sleep, schizophrenia, depression, Parkinson disease, and Alzheimer disease, the targets and the underlying mechanisms in the adult brain remain elusive.
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hal-00206212 , version 1 (16-01-2008)

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Mehdi Tafti, Norbert B Ghyselinck. Functional implication of the vitamin A signaling pathway in the brain.. Archives of Neurology -Chigago-, 2007, 64 (12), pp.1706-11. ⟨10.1001/archneur.64.12.1706⟩. ⟨hal-00206212⟩
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