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Article Dans Une Revue Tetrahedron Letters Année : 2007

Microwave-assisted solid-phase synthesis of hydantoin derivatives

Résumé

A microwave-assisted synthesis of 1,3,5-substituted hydantoins starting from various resins for solid-phase combinatorial chemistry has been developed. The hydantoins were synthesized from pre-loaded resins with amino acids via treatment with isocyanate or phenylisocyanate and subsequent intramolecular cyclization. Both reactions were performed under microwave irradiation. We studied the cyclative cleavage leading to hydantoin compounds dependent on the nature of the amino acid and the nucleofuge properties of the resin.

Domaines

Chimie organique
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Dates et versions

hal-00204482 , version 1 (02-02-2021)

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Evelina Colacino, Frédéric Lamaty, Jean Martinez, Isabelle Parrot. Microwave-assisted solid-phase synthesis of hydantoin derivatives. Tetrahedron Letters, 2007, 48 (30), pp.5317-5320. ⟨10.1016/j.tetlet.2007.05.084⟩. ⟨hal-00204482⟩
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