Synthesis and characterization of novel poly(g-benzyl-L-glutamate) derivatives tailored for the preparation of nanoparticles of pharmaceutical interest
Résumé
Four poly(γ-benzyl-L-glutamate) (PBLG) derivatives bearing at one end specific groups were synthesized by ring-opening polymerization of the corresponding γ-benzyl-L-glutamate N-carboxyanhydride using different amine-terminated initiators. These moieties were chosen to introduce, on demand, specific functionalities in nanoparticles of pharmaceutical interest. The PBLG and PBLG derivatives were characterized by 1H NMR, viscosimetry, Fourier transform infrared spectroscopy and differential scanning calorimetry. Nanoparticles smaller than 100 nm in diameter could be easily prepared from these PBLG derivatives by slight modification of a known nanoprecipitation technique.