Article Dans Une Revue Polymer international Année : 2007

Synthesis and characterization of novel poly(g-benzyl-L-glutamate) derivatives tailored for the preparation of nanoparticles of pharmaceutical interest

Résumé

Four poly(γ-benzyl-L-glutamate) (PBLG) derivatives bearing at one end specific groups were synthesized by ring-opening polymerization of the corresponding γ-benzyl-L-glutamate N-carboxyanhydride using different amine-terminated initiators. These moieties were chosen to introduce, on demand, specific functionalities in nanoparticles of pharmaceutical interest. The PBLG and PBLG derivatives were characterized by 1H NMR, viscosimetry, Fourier transform infrared spectroscopy and differential scanning calorimetry. Nanoparticles smaller than 100 nm in diameter could be easily prepared from these PBLG derivatives by slight modification of a known nanoprecipitation technique.

Dates et versions

hal-00199829 , version 1 (19-12-2007)

Identifiants

Citer

M.E. Martinez-Barbosa, V. Montembault, S. Cammas-Marion, G. Ponchel, Laurent Fontaine. Synthesis and characterization of novel poly(g-benzyl-L-glutamate) derivatives tailored for the preparation of nanoparticles of pharmaceutical interest. Polymer international, 2007, 56 (3), pp.317-324. ⟨10.1002/pi.2133⟩. ⟨hal-00199829⟩
156 Consultations
0 Téléchargements

Altmetric

Partager

  • More