Expression of Mona (monocytic adapter) in myeloid progenitor cells results in increased and prolonged MAP kinase activation upon macrophage colony-stimulating factor stimulation. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue FEBS Letters Année : 2000

Expression of Mona (monocytic adapter) in myeloid progenitor cells results in increased and prolonged MAP kinase activation upon macrophage colony-stimulating factor stimulation.

Résumé

Mona is an SH3 and SH2 domain-containing adapter molecule that is induced during monocytic differentiation. Here we have first shown that M-CSFR is the major Mona partner in M-CSF signaling, the interaction being mediated through tyrosine 697 of the receptor. Next we asked whether Mona expression would alter the Ras/MAP kinase pathway since Mona is a likely competitor of Grb2 for binding to M-CSFR. We found that M-CSF induced late and massive phosphorylation of ERK molecules in Mona-expressing myeloid cells compared to non-expressing cells. These results suggest that Mona expression might modify M-CSF signaling during monocytic differentiation.
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Dates et versions

hal-00192991 , version 1 (30-11-2007)

Identifiants

  • HAL Id : hal-00192991 , version 1
  • PUBMED : 11034310

Citer

C. Bourgin, R. Bourette, G. Mouchiroud, S. Arnaud. Expression of Mona (monocytic adapter) in myeloid progenitor cells results in increased and prolonged MAP kinase activation upon macrophage colony-stimulating factor stimulation.. FEBS Letters, 2000, 480 (2-3), pp.113-7. ⟨hal-00192991⟩
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