RTKdb: database of Receptor Tyrosine Kinase. - Archive ouverte HAL Access content directly
Journal Articles Nucleic Acids Research Year : 2003

RTKdb: database of Receptor Tyrosine Kinase.


Receptor Tyrosine Kinases (RTK) are transmembrane receptors specifically found in metazoans. They represent an excellent model for studying evolution of cellular processes in metazoans because they encompass large families of modular proteins and belong to a major family of contingency generating molecules in eukaryotic cells: the protein kinases. Because tyrosine kinases have been under close scrutiny for many years in various species, they are associated with a wealth of information, mainly in mammals. Presently, most categories of RTK were identified in mammals, but in a near future other model species will be sequenced, and will bring us RTKs from other metazoan clades. Thus, collecting RTK sequences would provide a good starting point as a new model for comparative and evolutionary studies applying to multigene families. In this context, we are developing the Receptor Tyrosine Kinase database (RTKdb), which is the only database on tyrosine kinase receptors presently available. In this database, protein sequences from eight model metazoan species are organized under the format previously used for the HOVERGEN, HOBACGEN and NUREBASE systems. RTKdb can be accessed through the PBIL (P?Bioinformatique Lyonnais) World Wide Web server at http://pbil.univ-lyon1.fr/RTKdb/, or through the FamFetch graphical user interface available at the same address.
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Dates and versions

hal-00192863 , version 1 (29-11-2007)


  • HAL Id : hal-00192863 , version 1
  • PUBMED : 12520021


Julien Grassot, Guy Mouchiroud, Guy Perrière. RTKdb: database of Receptor Tyrosine Kinase.. Nucleic Acids Research, 2003, 31 (1), pp.353-8. ⟨hal-00192863⟩
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