The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.
Christina A Cuomo
(1)
,
Ulrich Güldener
(2, 3)
,
Jin-Rong Xu
(4)
,
Frances Trail
(5)
,
B Gillian Turgeon
(6)
,
Antonio Di Pietro
(7)
,
Jonathan D Walton
(5)
,
Li-Jun Ma
(1)
,
Scott E Baker
(8)
,
Martijn Rep
(9)
,
Gerhard Adam
(10)
,
John Antoniw
(11)
,
Thomas Baldwin
(11)
,
Sarah Calvo
(1)
,
Yueh-Long Chang
(12)
,
David Decaprio
(1)
,
Liane R Gale
(12)
,
Sante Gnerre
(1)
,
Rubella S Goswami
(12)
,
Kim Hammond-Kosack
(11)
,
Linda J Harris
(13)
,
Karen Hilburn
(14)
,
John C Kennell
(15)
,
Scott Kroken
(16)
,
Jon K Magnuson
(8)
,
Gertrud Mannhaupt
(3)
,
Evan Mauceli
(1)
,
Hans-Werner Mewes
(2, 3)
,
Rudolf Mitterbauer
(10)
,
Gary Muehlbauer
(12)
,
Martin Münsterkötter
(3)
,
David L. Nelson
(17)
,
Kerry O'Donnell
(18)
,
Thérèse Ouellet
(13)
,
Weihong Qi
(5)
,
Hadi Quesneville
(19)
,
M Isabel G Roncero
(7)
,
Kye-Yong Seong
(12)
,
Igor V Tetko
(3, 20)
,
Martin Urban
(11)
,
Cees Waalwijk
(21)
,
Todd J Ward
(18)
,
Jiqiang Yao
(4)
,
Bruce W Birren
(1)
,
H Corby Kistler
(12, 14)
1
BROAD INSTITUTE -
Broad Institute of MIT and Harvard
2 TUM - Technische Universität Munchen - Technical University Munich - Université Technique de Munich
3 MIPS - Institute for Bioinformatics
4 Purdue University [West Lafayette]
5 Michigan State University [East Lansing]
6 Cornell University [New York]
7 Universidad de Córdoba = University of Córdoba [Córdoba]
8 PNNL - Pacific Northwest National Laboratory
9 UvA - University of Amsterdam [Amsterdam] = Universiteit van Amsterdam
10 BOKU - Universität für Bodenkultur Wien = University of Natural Resources and Life Sciences [Vienne, Autriche]
11 Rothamsted Research
12 UMN - University of Minnesota [Twin Cities]
13 AAFC - Agriculture and Agri-Food
14 USDA - U.S. Department of Agriculture - Agricultural Research Service - Cereal Disease Laboratory
15 SLU - Saint Louis University
16 University of Arizona
17 University of Tennessee Memphis
18 USDA ARS, - USDA ARS, National Center for Agricultural Utilization Research
19 IJM (UMR_7592) - Institut Jacques Monod
20 Institute of Bioorganic Chemistry and Photochemistry, National Ukrainian Academy of Sciences
21 PRI - Plant Research International
2 TUM - Technische Universität Munchen - Technical University Munich - Université Technique de Munich
3 MIPS - Institute for Bioinformatics
4 Purdue University [West Lafayette]
5 Michigan State University [East Lansing]
6 Cornell University [New York]
7 Universidad de Córdoba = University of Córdoba [Córdoba]
8 PNNL - Pacific Northwest National Laboratory
9 UvA - University of Amsterdam [Amsterdam] = Universiteit van Amsterdam
10 BOKU - Universität für Bodenkultur Wien = University of Natural Resources and Life Sciences [Vienne, Autriche]
11 Rothamsted Research
12 UMN - University of Minnesota [Twin Cities]
13 AAFC - Agriculture and Agri-Food
14 USDA - U.S. Department of Agriculture - Agricultural Research Service - Cereal Disease Laboratory
15 SLU - Saint Louis University
16 University of Arizona
17 University of Tennessee Memphis
18 USDA ARS, - USDA ARS, National Center for Agricultural Utilization Research
19 IJM (UMR_7592) - Institut Jacques Monod
20 Institute of Bioorganic Chemistry and Photochemistry, National Ukrainian Academy of Sciences
21 PRI - Plant Research International
Li-Jun Ma
- Fonction : Auteur
- PersonId : 759062
- ORCID : 0000-0002-2733-3708
Martijn Rep
- Fonction : Auteur
- PersonId : 759063
- ORCID : 0000-0003-3608-6283
Hadi Quesneville
- Fonction : Auteur
- PersonId : 736048
- IdHAL : hadi-quesneville
- ORCID : 0000-0003-3001-4908
- IdRef : 137542860
Résumé
We sequenced and annotated the genome of the filamentous fungus Fusarium graminearum, a major pathogen of cultivated cereals. Very few repetitive sequences were detected, and the process of repeat-induced point mutation, in which duplicated sequences are subject to extensive mutation, may partially account for the reduced repeat content and apparent low number of paralogous (ancestrally duplicated) genes. A second strain of F. graminearum contained more than 10,000 single-nucleotide polymorphisms, which were frequently located near telomeres and within other discrete chromosomal segments. Many highly polymorphic regions contained sets of genes implicated in plant-fungus interactions and were unusually divergent, with higher rates of recombination. These regions of genome innovation may result from selection due to interactions of F. graminearum with its plant hosts.