Intranasal cowpox virus infection of the mouse as a model for preclinical evaluation of smallpox vaccines. - Archive ouverte HAL Access content directly
Journal Articles Vaccine Year : 2007

Intranasal cowpox virus infection of the mouse as a model for preclinical evaluation of smallpox vaccines.

Audrey Ferrier-Rembert
  • Function : Author
Jean-Nicolas Tournier
Daniel Garin
  • Function : Author
Jean-Marc Crance
  • Function : Author

Abstract

The intranasal infection of mice with cowpox virus (CPXV) has been evaluated as a model for smallpox infection in man. Administration of a lethal dose of CPXV allowed time for development of T-cell responses but antibodies could not be detected before death occurred. In contrast, infection with a sublethal dose was associated with an early T-cell response followed by neutralising antibodies which correlated with virus clearance. Comparison of two first generation smallpox vaccines revealed no significant differences in terms of immunogenicity, protection and post-challenge virus clearance. These studies show that the CPXV/mouse model is valuable for the initial assessment of smallpox vaccines.

Dates and versions

hal-00189992 , version 1 (22-11-2007)

Identifiers

Cite

Audrey Ferrier-Rembert, Robert Drillien, Jean-Nicolas Tournier, Daniel Garin, Jean-Marc Crance. Intranasal cowpox virus infection of the mouse as a model for preclinical evaluation of smallpox vaccines.. Vaccine, 2007, 25 (25), pp.4809-17. ⟨10.1016/j.vaccine.2007.04.011⟩. ⟨hal-00189992⟩
32 View
0 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More