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Article Dans Une Revue EMBO Journal Année : 2006

Endocrine functions of bile acids.

Résumé

Bile acids (BAs), a group of structurally diverse molecules that are primarily synthesized in the liver from cholesterol, are the chief components of bile. Besides their well-established roles in dietary lipid absorption and cholesterol homeostasis, it has recently emerged that BAs are also signaling molecules, with systemic endocrine functions. BAs activate mitogen-activated protein kinase pathways, are ligands for the G-protein-coupled receptor TGR5, and activate nuclear hormone receptors such as farnesoid X receptor alpha. Through activation of these diverse signaling pathways, BAs can regulate their own enterohepatic circulation, but also triglyceride, cholesterol, energy, and glucose homeostasis. Thus, BA-controlled signaling pathways are promising novel drug targets to treat common metabolic diseases, such as obesity, type II diabetes, hyperlipidemia, and atherosclerosis.

Dates et versions

hal-00187960 , version 1 (15-11-2007)

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Citer

Sander M Houten, Mitsuhiro Watanabe, Johan Auwerx. Endocrine functions of bile acids.. EMBO Journal, 2006, 25 (7), pp.1419-25. ⟨10.1038/sj.emboj.7601049⟩. ⟨hal-00187960⟩
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