Enhancer sequence conservation between vertebrates is favoured in developmental regulator genes. - Archive ouverte HAL Access content directly
Journal Articles Trends in Genetics Year : 2005

Enhancer sequence conservation between vertebrates is favoured in developmental regulator genes.

Abstract

Sequence conservation has been used to find genes and to pinpoint functional non-coding sequences such as transcriptional regulatory elements. In this article, we analysed the conservation of 104 experimentally validated murine enhancer sequences between the mouse and zebrafish genomes. Surprisingly, only 10.5% of the mouse enhancers have homologues in zebrafish. All of the genes with conserved cis-elements have regulatory functions during embryonic development, perhaps reflecting substantial structural constraints on the integration of spatio-temporal signalling cues during the formation of the vertebrate body.

Dates and versions

hal-00187725 , version 1 (15-11-2007)

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Charles Plessy, Thomas Dickmeis, Frédéric Chalmel, Uwe Strähle. Enhancer sequence conservation between vertebrates is favoured in developmental regulator genes.. Trends in Genetics, 2005, 21 (4), pp.207-10. ⟨10.1016/j.tig.2005.02.006⟩. ⟨hal-00187725⟩
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