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Journal Articles Current Opinion in Genetics and Development Year : 2005

Structural and functional features of transcription factors controlling the circadian clock.

Abstract

Most organisms adapt the timing of their physiology to the cyclic changes of the environment with the use of intrinsic time-keeping systems called circadian clocks. Central features of the molecular clock mechanism are transcription- and translation-based negative feedback loops: clock genes and their products interact to generate oscillation of specific transcripts and proteins, and, ultimately, circadian rhythmicity and behavior. Various transcription factors constitute the molecular clock, and the signal transduction cascades governing their function appear to be crucial for the fine-tuning of the circadian cycle.

Dates and versions

hal-00187560 , version 1 (14-11-2007)

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Jun Hirayama, Paolo Sassone-Corsi. Structural and functional features of transcription factors controlling the circadian clock.. Current Opinion in Genetics and Development, 2005, 15 (5), pp.548-56. ⟨10.1016/j.gde.2005.07.003⟩. ⟨hal-00187560⟩
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