Mouse phenogenomics: the fast track to "systems metabolism". - Archive ouverte HAL Access content directly
Journal Articles Cell Metabolism Year : 2005

Mouse phenogenomics: the fast track to "systems metabolism".

Abstract

With the completion of the many genomes, genetics is positioned to meet physiology. In this review, we summarize the coming of "systems metabolism" in mammals through the use of the mouse, as a model system to study metabolism. Building on mouse genetics with increasingly sophisticated clinical and molecular phenotyping strategies has enabled scientists to now tackle complex biomedical questions, such as those related to the pathogenesis of the common metabolic disorders. The ultimate goal of such strategies will be to mimic human metabolism with the click of a mouse.

Dates and versions

hal-00187326 , version 1 (14-11-2007)

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Carmen A Argmann, Pierre Chambon, Johan Auwerx. Mouse phenogenomics: the fast track to "systems metabolism".. Cell Metabolism, 2005, 2 (6), pp.349-60. ⟨10.1016/j.cmet.2005.11.002⟩. ⟨hal-00187326⟩
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