Article Dans Une Revue Synthesis: Journal of Synthetic Organic Chemistry Année : 2003

Synthesis of New Arylhydroxymethylphosphinic Acids and Derivatives

Résumé

The synthesis of a new series of arylhydroxymethylphosphinic acid derivatives is described. The protected compounds were prepared by a palladium(0) catalysed arylation of ethyl benzyloxymethylphosphinate with aryl halides. Subsequent hydrogenolysis of the benzyl protecting group followed by acidic hydrolysis of the ester function readily afforded the target compounds. Selective removal of the ester group was achieved by basic hydrolysis whereas acidic hydrolysis directly gave the totally deprotected compounds.

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Dates et versions

hal-00178092 , version 1 (10-10-2007)

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Henri-Jean Cristau, Agnès Hervé, François Loiseau, David Null Virieux. Synthesis of New Arylhydroxymethylphosphinic Acids and Derivatives. Synthesis: Journal of Synthetic Organic Chemistry, 2003, 14, pp.2216-2220. ⟨10.1055/s-2003-41045⟩. ⟨hal-00178092⟩
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