IL-6, TNF-alpha and atherosclerosis risk indicators in a healthy family population: the STANISLAS cohort. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Atherosclerosis Année : 2003

IL-6, TNF-alpha and atherosclerosis risk indicators in a healthy family population: the STANISLAS cohort.

Résumé

There are no satisfactory data on circulating concentrations of inflammatory cytokines and their potential relationship with traditional and nontraditional atherosclerosis risk factors in a large healthy young population. The present study was conducted to examine, in 179 healthy families selected from the STANISLAS cohort, the association between interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), orosomucoid, haptoglobin, cell-adhesion molecules (ICAM-1, E-, L- and P-selectin) and lipid parameter concentrations. Age, BMI, white blood cells and tobacco consumption contributed to the variation of IL-6 concentrations. Age and tobacco contributed also to TNF-alpha variation. Taking into account potential covariates, we showed strong positive correlation between IL-6 and both inflammatory markers TNF-alpha and CRP in parents and in offspring (P<0.001). In parents, IL-6 was associated with ICAM-1 and L-selectin (P<0.01), while IL-6 and TNF-alpha predicted E-selectin in offspring only (0.001

Dates et versions

hal-00176481 , version 1 (03-10-2007)

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Nadia Haddy, Catherine Sass, Suzanne Droesch, Mohamed Zaiou, Gérard Siest, et al.. IL-6, TNF-alpha and atherosclerosis risk indicators in a healthy family population: the STANISLAS cohort.. Atherosclerosis, 2003, 170 (2), pp.277-83. ⟨10.1038/sj.ejhg.5200864⟩. ⟨hal-00176481⟩
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