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Article Dans Une Revue Immunity Année : 2003

The T cell surface--how well do we know it?

Résumé

The overall degree of complexity of the T cell surface has been unclear, constraining our understanding of its biology. Using global gene expression analysis, we show that 111 of 374 genes encoding well-characterized leukocyte surface antigens are expressed by a resting cytotoxic T cell. Unexpectedly, of 97 stringently defined, T cell-specific transcripts with unknown functions that we identify, none encode proteins with the modular architecture characteristic of 80% of leukocyte surface antigens. Only two encode proteins with membrane topologies found exclusively in cell surface molecules. Our analysis indicates that the cell type-specific composition of the resting CD8+ T cell surface is now largely defined, providing an insight into the overall compositional complexity of the mammalian cell surface and a framework for formulating systematic models of T cell surface-dependent processes, such as T cell receptor triggering.

Domaines

Immunologie
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Dates et versions

hal-00170979 , version 1 (11-09-2007)

Identifiants

  • HAL Id : hal-00170979 , version 1
  • PUBMED : 12932355

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Edward J Evans, Lawrence Hene, Lisa M Sparks, Tao Dong, Christelle Retiere, et al.. The T cell surface--how well do we know it?. Immunity, 2003, 19 (2), pp.213-23. ⟨hal-00170979⟩
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