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Article Dans Une Revue Bioorganic and Medicinal Chemistry Année : 2006

Synthesis of novel 5-substituted indirubins as protein kinases inhibitors

Résumé

In an effort to identify new pharmacological inhibitors of disease-relevant protein kinases with increased potency and selectivity, we synthesized and evaluated new 5-substituted indirubins. The effects of 34 indirubin derivatives on CDK1/cyclin B, CDK5/p25, and GSK-3, as well as on SH-SY5Y human neuroblastoma cell survival, were investigated.

Dates et versions

hal-00169371 , version 1 (03-09-2007)

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Anne Beauchard, Yoan Ferandin, Stéphane Frère, Olivier Lozach, Mélina Blairvacq, et al.. Synthesis of novel 5-substituted indirubins as protein kinases inhibitors. Bioorganic and Medicinal Chemistry, 2006, 14 (18), pp.6434-43. ⟨10.1016/j.bmc.2006.05.036⟩. ⟨hal-00169371⟩
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