Failure of zanamivir therapy for pneumonia in a bone-marrow transplant recipient infected by a zanamivir-sensitive influenza A (H1N1) virus. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Antiviral Therapy Année : 2007

Failure of zanamivir therapy for pneumonia in a bone-marrow transplant recipient infected by a zanamivir-sensitive influenza A (H1N1) virus.

Résumé

Influenza A viruses are responsible for significant morbidity and mortality after bone marrow transplantation. Here we report failure of inhaled zanamivir treatment in a bone-marrow transplant recipient with pneumonia caused by an influenza A (H1N1) virus, although the influenza viruses isolated from bronchoalveolar lavages before and after treatment were clearly found to be sensitive to zanamivir using cell-based and enzymatic assays. Subsequent oral treatment with oseltamivir allowed complete recovery. Poor bioavailability of zanamivir in the peripheral lungs might have been limiting treatment efficacy in such an immunocompromised patient.

Domaines

Virologie
Fichier non déposé

Dates et versions

hal-00167799 , version 1 (23-08-2007)

Identifiants

  • HAL Id : hal-00167799 , version 1
  • PUBMED : 17668567

Citer

Rita Medeiros, Marie-Anne Rameix-Welti, Valérie Lorin, Patricia Ribaud, Jean-Claude Manuguerra, et al.. Failure of zanamivir therapy for pneumonia in a bone-marrow transplant recipient infected by a zanamivir-sensitive influenza A (H1N1) virus.. Antiviral Therapy, 2007, 12 (4), pp.571-6. ⟨hal-00167799⟩
139 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More