Maintenance of HIV-specific central and effector memory CD4 and CD8 T cells requires antigen persistence. - Archive ouverte HAL Access content directly
Journal Articles AIDS Research and Human Retroviruses Year : 2007

Maintenance of HIV-specific central and effector memory CD4 and CD8 T cells requires antigen persistence.

Urban Sester
  • Function : Author
Hans Köhler
  • Function : Author
Hans W Pees
  • Function : Author
Barbara C Gärtner
  • Function : Author
Simon Wain-Hobson
  • Function : Author
  • PersonId : 858308
Gennady Bocharov
  • Function : Author
Andreas Meyerhans

Abstract

The HIV-specific central and effector CD4 and CD8 memory T cell populations disappear from the peripheral blood of infected individuals under highly active antiretroviral therapy (HAART) with a mean half-life of 6.0 and 7.7 months, respectively. By contrast, cytomegalovirus (CMV)-specific responses are stable or increase. The striking quantitative differences between T cell memory to two persistent viral infections are instructive as to how antigen dosage contributes to the maintenance of antigen-specific memory T cell responses in humans.
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hal-00167684 , version 1 (22-08-2007)

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Urban Sester, Martina Sester, Hans Köhler, Hans W Pees, Barbara C Gärtner, et al.. Maintenance of HIV-specific central and effector memory CD4 and CD8 T cells requires antigen persistence.. AIDS Research and Human Retroviruses, 2007, 23 (4), pp.549-53. ⟨10.1089/aid.2006.0234⟩. ⟨hal-00167684⟩
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