Integration of a pAL2-1 homologous mitochondrial plasmid associated with life span extension in Podospora anserina. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Fungal Genetics and Biology Année : 2007

Integration of a pAL2-1 homologous mitochondrial plasmid associated with life span extension in Podospora anserina.

Résumé

We isolated and characterized a novel spontaneous longevity mutant of Podospora anserina strain Wa32 carrying one of the pAL2-1 homologous mitochondrial plasmids. This mutant is at least ten fold longer-lived than the wild type, and is hence a formal suppressor of both the regular and the 'plasmid-based' senescence process. We show that the longevity trait is maternally inherited and coincides with the presence of a copy of the plasmid integrated in the 5' UTR of the mitochondrial Complex I genes nd2 and nd3. This mutation is associated with complex alterations in the respiratory chain, including a dispensable induction of the alternative oxidase. It is also associated with a stabilization of the mitochondrial chromosome and a reduction of the overall cellular level of reactive oxygen species.

Dates et versions

hal-00167495 , version 1 (21-08-2007)

Identifiants

Citer

M. F. P. M. Maas, C. H. Sellem, R. F. Hoekstra, A. J. M. Debets, A. Sainsard-Chanet. Integration of a pAL2-1 homologous mitochondrial plasmid associated with life span extension in Podospora anserina.. Fungal Genetics and Biology, 2007, 44 (7), pp.659-71. ⟨10.1016/j.fgb.2006.10.007⟩. ⟨hal-00167495⟩
8 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More