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Article Dans Une Revue Tetrahedron Letters Année : 2007

Synergic effect of hydride and proton donors in the Pd(0)-mediated deprotection of Nα-Aloc proline derivatives

Résumé

In this study, the challenging Pd(0)-catalyzed Nα-Aloc removal from a proline residue using Me2NH·BH3 or PhSiH3 as allyl scavengers has been investigated. Standard conditions led to a large amount of an allylamine byproduct. A careful study of the reactions allowed us to design the optimal conditions for the quick and quantitative formation of the desired product, while taking advantage of a synergic effect between hydride and proton donors.

Dates et versions

hal-00166600 , version 1 (07-08-2007)

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Citer

Isidore P. Decostaire, Dominique Lelièvre, Vincent Aucagne, Agnès F. Delmas. Synergic effect of hydride and proton donors in the Pd(0)-mediated deprotection of Nα-Aloc proline derivatives. Tetrahedron Letters, 2007, 48, pp.6523-6526. ⟨10.1016/j.tetlet.2007.07.061⟩. ⟨hal-00166600⟩
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