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Article Dans Une Revue Current Opinion in Microbiology Année : 2005

Brucella lipopolysaccharide acts as a virulence factor.

Ignacio Moriyon
  • Fonction : Auteur
Edgardo Moreno
  • Fonction : Auteur
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Résumé

Brucella is a facultative intracellular bacterium responsible for brucellosis. Virulence factors involved in Brucella replication and Brucella's strategies to circumvent the immune response are under investigation. VirB proteins that form the type IV secretion system and that are involved in intracellular replication are considered as one of Brucella's virulence factors. In addition to this secretion system, bacterial outer membrane components have also been described as being implicated in Brucella survival in the host. For example, this bacterium possesses an unconventional non-endotoxic lipopolysaccharide that confers resistance to anti-microbial attacks and modulates the host immune response. These properties make lipopolysaccharide an important virulence factor for Brucella survival and replication in the host.

Domaines

Immunologie

Dates et versions

hal-00165710 , version 1 (27-07-2007)

Identifiants

Citer

Nicolas Lapaque, Ignacio Moriyon, Edgardo Moreno, Jean-Pierre Gorvel. Brucella lipopolysaccharide acts as a virulence factor.. Current Opinion in Microbiology, 2005, 8 (1), pp.60-6. ⟨10.1016/j.mib.2004.12.003⟩. ⟨hal-00165710⟩

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