Clink, a nanovirus-encoded protein, binds both pRB and SKP1. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Virology Année : 2000

Clink, a nanovirus-encoded protein, binds both pRB and SKP1.

Résumé

Clink, a 20-kDa protein of faba bean necrotic yellows virus, a single-stranded DNA plant virus, interacts with pRB family members and a SKP1 homologue from Medicago sativa. An LxCxE motif and an F-box of Clink mediate the interactions with the respective proteins. The capacity of Clink to bind pRB correlates with its ability to stimulate viral replication. Interaction of a single protein with the cell cycle regulator pRB and SKP1, a constituent of the ubiquitin-protein turnover pathway, appears to be a novel feature. Hence, Clink may represent a new class of viral cell cycle modulators.
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Dates et versions

hal-00160987 , version 1 (09-07-2007)

Identifiants

  • HAL Id : hal-00160987 , version 1
  • PUBMED : 10708410

Citer

M. N. Aronson, A. D. Meyer, J. Györgyey, L. Katul, H. J. Vetten, et al.. Clink, a nanovirus-encoded protein, binds both pRB and SKP1.. Journal of Virology, 2000, 74 (7), pp.2967-72. ⟨hal-00160987⟩
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