The multiobjective optimization of Slide-o-Cam is reported in this paper. Slide-o-Cam is a cam mechanism with multiple rollers mounted on a common translating follower. This transmission provides pure-rolling motion, thereby reducing the friction of rack-and-pinions and linear drives. A Pareto frontier is obtained by means of multiobjective optimization. This optimization is based on three objective functions: (i) the pressure angle, which is a suitable performance index for the transmission because it determines the amount of force transmitted to the load vs. that transmitted to the machine frame; (ii) the Hertz pressure used to evaluate the stresses produced on the contact surface between cam and roller; and (iii) the size of the mechanism, characterized by the number of cams and their width.