Synthesis of a staurosporine analogue possessing a 7-azaindole unit instead of an indole moiety
Résumé
The synthesis of a new staurosporine analogue possessing a 7-azaindole unit instead of an indole moiety is described. This synthesis could be achieved by coupling a sugar moiety previously tosylated in 2′ position to the azaindolocarbazole aglycone. Nucleophilic substitution on the carbon bearing the tosyl group yielded to the key cyclization leading to a compound in which the carbohydrate part is linked to both indole and azaindole nitrogens
Domaines
Chimie organique| Origine | Fichiers produits par l'(les) auteur(s) |
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