Structural comparison of three crystalline complexes of a peptidic toxin with a synaptic acetylcholine recognition protein. - Archive ouverte HAL Access content directly
Journal Articles Journal of Molecular Neuroscience Year : 2006

Structural comparison of three crystalline complexes of a peptidic toxin with a synaptic acetylcholine recognition protein.

Yves Bourne
Scott B Hansen
  • Function : Author
Gerlind Sulzenbacher
Todd T Talley
  • Function : Author
Tom Huxford
  • Function : Author
Palmer Taylor
  • Function : Author
Pascale Marchot

Abstract

Many peptidic toxins from animal venoms target neuronal or peripheral synaptic receptors with high affinities and specificities. Hence, these toxins are not only potent natural weapons but also precise molecular tools for pharmacological studies of their receptors. Although they belong to various structural and/or functional subfamilies, they often share similar molecular features, such as a highly reticulated scaffold presenting specific binding determinants.
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Dates and versions

hal-00134316 , version 1 (01-03-2007)

Identifiers

  • HAL Id : hal-00134316 , version 1
  • PUBMED : 17192648

Cite

Yves Bourne, Scott B Hansen, Gerlind Sulzenbacher, Todd T Talley, Tom Huxford, et al.. Structural comparison of three crystalline complexes of a peptidic toxin with a synaptic acetylcholine recognition protein.. Journal of Molecular Neuroscience, 2006, 30 (1-2), pp.103-4. ⟨hal-00134316⟩

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