Mitochondrial metabolism and aging in the filamentous fungus Podospora anserina. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue BBA - Biochimica et Biophysica Acta Année : 2006

Mitochondrial metabolism and aging in the filamentous fungus Podospora anserina.

Résumé

The filamentous fungus Podospora anserina has a limited lifespan. In this organism, aging is systematically associated to mitochondrial DNA instability. We recently provided evidence that the respiratory function is a key determinant of its lifespan. Loss of function of the cytochrome pathway leads to the compensatory induction of an alternative oxidase, to a decreased production of reactive oxygen species and to a striking increase in lifespan. These changes are associated to the stabilization of the mitochondrial DNA. Here we review and discuss the links between these different parameters and their implication in the control of lifespan. Since we demonstrated the central role of mitochondrial metabolism in aging, the same relationship has been evidenced in several model systems from yeast to mice, confirming the usefulness of simple organisms as P. anserina for studying lifespan regulation.

Dates et versions

hal-00132685 , version 1 (22-02-2007)

Identifiants

Citer

Séverine Lorin, Eric Dufour, Annie Sainsard-Chanet. Mitochondrial metabolism and aging in the filamentous fungus Podospora anserina.. BBA - Biochimica et Biophysica Acta, 2006, 1757 (5-6), pp.604-10. ⟨10.1016/j.bbabio.2006.03.005⟩. ⟨hal-00132685⟩
34 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More