Synthesis and antiproliferative activities of indolin-2-one derivatives bearing amino acid moieties.
Résumé
A convenient synthesis of indolin-2-ones substituted in the 3 position by an aminomethylene group bearing different amino acid moieties is described. Their antiproliferative activities were evaluated toward a panel of human solid tumor cell lines (PC 3, DLD-1, MCF-7, M4 Beu, A549, PA 1) and healthy cell lines (a murine fibroblast L929 and a human fibroblast primary culture)
Domaines
Chimie organique| Origine | Fichiers produits par l'(les) auteur(s) |
|---|