A study of interlaboratory influence on column evaluation. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Pharmaceutical and Biomedical Analysis Année : 2005

A study of interlaboratory influence on column evaluation.

Résumé

A liquid chromatography method for the characterization of base deactivated columns was investigated in a collaborative study involving six laboratories. This work was carried out on two chromatographic supports (Xterra RP 18 and Symmetry Shield). Different cooling systems, namely water bath and air oven, were tested and it was shown that column thermoregulation did not significantly influence chromatographic data. In order to control the mobile phase composition, the latter was prepared by weight rather than volume. Thanks to the injection of a set of selected neutral compounds, extra-column effects were evaluated in each of the participating laboratories. The results showed that chromatographic supports tested in different laboratories and following the same test protocol could be effectively compared
Fichier non déposé

Dates et versions

hal-00114179 , version 1 (15-11-2006)

Identifiants

  • HAL Id : hal-00114179 , version 1

Citer

Cinzia Stella, Sabine Heinisch, Xiangli Liu, Pierre-Alain Carrupt, Gabriel Cazorla, et al.. A study of interlaboratory influence on column evaluation.. Journal of Pharmaceutical and Biomedical Analysis, 2005, 39(1-2), pp.104-110. ⟨hal-00114179⟩
225 Consultations
0 Téléchargements

Partager

Gmail Mastodon Facebook X LinkedIn More