Control of human thymocyte migration by Neuropilin-1/Semaphorin-3A mediated interactions. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 2007

Control of human thymocyte migration by Neuropilin-1/Semaphorin-3A mediated interactions.

Résumé

It is largely established that molecules first discovered in the nervous system are also found in the immune system. Neuropilin-1 (NP-1) was initially identified to mediate semaphorin-induced chemorepulsion during brain development and is also involved in peripheral T cell/dendritic cell interactions. Herein, we studied NP-1 during T cell development in the human thymus. NP-1 is expressed in both cortex and medulla of thymic lobules, being found in distinct CD4/CD8-defined thymocyte subsets. NP-1 is also found in thymic epithelial cells (TEC) in situ and in vitro, and is recruited at the site of TEC-thymocyte contact. Moreover, NP-1 was rapidly up-regulated during thymocyte stimulation by T cell receptor (TCR) and IL-7 or after adhesion to TEC. Semaphorin-3A (Sema-3A), a natural ligand of NP-1, is also present in human thymus, both in TEC and thymocytes, being up-regulated in thymocytes after TCR engagement. Functionally, Sema-3A decreases the adhesion capacity of NP-1(+) thymocytes and induces their migration by a repulsive effect. In conclusion, we show here that NP-1/Sema-3A-mediated interactions participate in the control of human thymocyte development.

Dates et versions

hal-00092590 , version 1 (11-09-2006)

Identifiants

Citer

Y. Lepelletier, S. Smaniotto, R. Hadj-Slimane, D.M. Villa-Verde, A.C. Nagueira, et al.. Control of human thymocyte migration by Neuropilin-1/Semaphorin-3A mediated interactions.. Proceedings of the National Academy of Sciences of the United States of America, 2007, 104, pp.5545-5550. ⟨10.1073/pnas.0700705104⟩. ⟨hal-00092590⟩

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