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Article Dans Une Revue Current Opinion in Pharmacology Année : 2005

Botulinal neurotoxins : revival of an old killer

Résumé

Botulinal neurotoxins (BoNTs) produced by anaerobic bacteria of the genus Clostridium are the most toxic proteins known, with mouse LD50 values in the range of 1–5 ng/kg. They are responsible for the pathophysiology of botulism. BoNTs are metalloproteinases that enter peripheral cholinergic nerve terminals, where they cleave one or two of the three core proteins of the neuroexocytosis apparatus and elicit persistent but reversible inhibition of neurotransmitter release. Their specificity of action has made them useful therapeutic agents for many human syndromes caused by hyperactivity of cholinergic nerve terminals. Their range of clinical applications is continuously growing, and BoNT/A is being used extensively as a pharmaco-cosmetic.

Domaines

Neurobiologie

Dates et versions

hal-00088165 , version 1 (31-07-2006)

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Citer

Cesare Montecucco, Jordi Molgó. Botulinal neurotoxins : revival of an old killer. Current Opinion in Pharmacology, 2005, 5(3), pp.274-279. ⟨10.1016/j.coph.2004.12.006⟩. ⟨hal-00088165⟩

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