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Article Dans Une Revue Current Drug Targets Année : 2003

The adenine nucleotide translocator: a new potential chemotherapeutic target.

A.S. Belzacq
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Catherine Brenner

Résumé

Identification of new targets is of utmost importance for the development of efficient apoptosis-modulating drugs. This has become possible from the unraveling of the basic apoptosis mechanisms and notably, from the demonstration of the mitochondrial membrane permeabilization as a central rate-limiting step of numerous models of cell death. Indeed, molecular and pharmacological studies revealed that the adenine nucleotide translocator (ANT) could be a therapeutic target. First, ANT is a bi-functional protein. It mediates the exchange of cytosolic ADP and mitochondrial ATP, and contributes to apoptosis via its capacity to become a lethal pore. Second, both ANT functions are under the control of the (anti)-oncogenes from the Bax/Bcl-2 family, and third, agents as diverse as proteins, lipids, ions, pro-oxidants or chemotherapeutic agents directly modulate the pore-forming activity of ANT. Here, we will review the mode of apoptosis induction by various classes of chemotherapeutic agents, which all influence directly ANT pro-apoptotic function. Hopefully, this will yield several clues to the modulation of apoptosis from a therapeutic perspective.
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Dates et versions

hal-00086057 , version 1 (17-07-2006)

Identifiants

  • HAL Id : hal-00086057 , version 1

Citer

A.S. Belzacq, Catherine Brenner. The adenine nucleotide translocator: a new potential chemotherapeutic target.. Current Drug Targets, 2003, 4, pp.517-524. ⟨hal-00086057⟩
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