Fast evolution of Interleukine-2 in mammals, ans positive selection in ruminants. - Archive ouverte HAL
Article Dans Une Revue Journal of Molecular Evolution Année : 2000

Fast evolution of Interleukine-2 in mammals, ans positive selection in ruminants.

D. Zelus
  • Fonction : Auteur
M. Delacre
  • Fonction : Auteur
M. Robinson
  • Fonction : Auteur
C. Auriault
  • Fonction : Auteur

Résumé

Interleukin-2 (IL-2) is a cytokine involved in induction and regulation of the immune response in mammals. There have been numerous reports about the search for IL-2 in species other than mammals, and recently an IL-2-like gene has been isolated in chicken. Using PCR, we searched for IL-2 gene sequences in a wide variety of mammals, including marsupials and monotremes, as well as in birds. Although we can readily amplify IL-2 gene fragments in placental mammals, no amplification was obtained in other species. This is best explained by very high substitution rates. This suggest that strategies to isolate IL-2 homologous genes outside mammals should involve functional assays, as for the chicken gene, and not hybridization-based techniques. Nonsynonymous substitution rates are especially high in ruminants, due to positive selection acting on regions important in term of structure-function. We suggest that, although globally similar, the immune response of various mammals is not identical, mainly at the level of cytokine-mediated regulations.
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Dates et versions

hal-00023795 , version 1 (04-05-2006)

Identifiants

  • HAL Id : hal-00023795 , version 1
  • PRODINRA : 248953

Citer

D. Zelus, M. Delacre, M. Robinson, C. Auriault, Vincent Laudet. Fast evolution of Interleukine-2 in mammals, ans positive selection in ruminants.. Journal of Molecular Evolution, 2000, 51, pp.234-244. ⟨hal-00023795⟩
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