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Article Dans Une Revue (Article De Synthèse) Parasitology Today Année : 2000

Hormones and nuclear receptors in schistosome development.

R.L. de Mendonca
  • Fonction : Auteur
H. Escriva
D. Bouton
  • Fonction : Auteur
R. Pierce
  • Fonction : Auteur

Résumé

A substantial but disparate body of evidence suggests that hormones affect the development of schistosomes within their definitive hosts. Here, Raymond Pierce and colleagues review such evidence for host steroid and thyroid hormones, and for ecdysteroids, and link this to the expanding knowledge of the nuclear receptors for these hormones. Phylogenetic analysis of the nuclear receptor superfamily and the characterization of the first schistosome nuclear receptors suggest that steroids and thyroid hormone probably act indirectly, or by pathways not involving the control of gene transcription. However, the probability that schistosome nuclear receptors exist for a variety of unique ligands opens up exciting possibilities for targeted drug development.

Dates et versions

hal-00023766 , version 1 (04-05-2006)

Identifiants

Citer

R.L. de Mendonca, H. Escriva, D. Bouton, Vincent Laudet, R. Pierce. Hormones and nuclear receptors in schistosome development.. Parasitology Today, 2000, 16 (6), pp.233-240. ⟨10.1016/S0169-4758(00)01641-0⟩. ⟨hal-00023766⟩
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