As a model catalyst, late transition and noble metal nano-clusters supported on MgO(1 0 0) have been the subject of numerous detailed experimental studies. Understanding their morphology, the relation between their size, the detailed atomic structure, and the interaction with the oxide substrate is a first and necessary step towards the control of their reactivity. From the theoretical point of view, if ab initio methods have proved their usefulness in the description of interactions at metal/oxide interfaces, the computational effort necessary for a realistic description of larger-size systems disables their use for simulations of cluster structures which have been experimentally observed. This is why we have proposed an effective approach to simulate non-reactive deposition of nano-scale metal objects on surfaces of highly ionic oxides. Its core is a many-body potential energy surface derived from results of ab initio calculations for model metal/oxide interface structures.