Tenascin-C targeting strategies in cancer
Mots clés
fluorescein isothiocyanate
FN
fibronectin
FNIII
fibronectin type III repeat
g
gram
68Ga
gallium-68
GBM
glioblastoma
HAMA
human-anti-mouse antibody
HCAb
heavy-chain-only antibody
HER2
human epidermal growth factor receptor 2
HL
Hodgkin's lymphoma
HLA
human leucocyte antigen
HLE-B3
human lens epithelial cells
HNSCC
head and neck squamous cell carcinoma
HSCT
hematopoietic stem cell transplantation
hTNC
human TNC
HUVEC
human umbilical vein endothelial cells
IC50
inhibitory concentration 50
ID
injected dose
IF
immunofluorescence
IgG
immunoglobulin G
IHC
immunohistochemistry
131I
iodine-131
IL
interleukin
IU
international unit
Kd
equilibrium dissociation constant
kDa
kilodalton
KPS
Karnofsky performance status
KRAS
Kirsten rat sarcoma viral oncogene
LNA
locked nucleic acid
177Lu
lutetium-177
mAb
monoclonal antibody
mg
milligram
ml
milliliter
ng
nanogram
MAREMO
matrix regulating motif
MBS
MAREMO binding site
MFR
magnetic fluorescent radioisotope
mRNA
messenger RNA
Tenascin-C Extracellular matrix Biomarker Diagnostic application Therapeutic approach Tumor Cancer Inflammation Antibody Nanobody Aptamer Peptide Tumor immunity ADA
miRNA
anti-drug antibodies ADCC
microRNA
antibody-dependent cell mediated cytotoxicity ADC
MMTV-NeuNT
antibody-drug-conjugate AgNPs
mouse mammary tumor virus-NeuNT
metallic silver nanoparticles ApoE
MR
apolipoprotein E 211At
magnetic resonance
astatine-211 AML
MTD
acute myeloid leukemia BALB
maximum tolerated dose
bagg albino CAF
Nb
carcinoma associated fibroblasts CAIA
nanobody
collagen antibody induced arthritis CAR-T
NB
chimeric antigen receptor-T cell CCR
nanobubbles
C-chemokine receptor CCL21
NHL
chemokine ligand 21 CD
non-Hodgkin lymphoma
cluster differentiation CDR
NK
complementarity-determining regions ch
natural killer cell
chimeric CPTD
nM
camptothecin prodrug CR
nanomolar
complete response Cri
4NQO
incomplete count recovery 64Cu
4-Nitroquinoline 1-oxide
copper-64 CXCL
NRP-1
C-X-C motif chemokine ligand DAMP
neuropilin-1
danger associated molecular pattern DNA
NP
deoxyribonucleic acid DOTA
nanoparticle
dodecane tetraacetic acid DOX
NSLC
doxorubicin ECM
non-small lung carcinomas
extracellular matrix EDA
NW
extra domain A EGFL
nanoworm
epidermal growth factor-like repeats EGFR
OS
epidermal growth factor receptor ELISA
overall survival
enzyme-linked immunosorbent assay EMT
OSCC
epithelial mesenchymal transition 18F
oral squamous cell carcinoma
fluorodeoxyglucose Fab
PAGRIT
fragment antigen-binding FAM
pretargeted antibody-guided radioimmunotherapy
fluorescein FBG
PC-3
fibrinogen like globular domain Fc
prostate carcinoma cells
fragment cristallin FITC
PDAC
fluorescein isothiocyanate FN
pancreatic ductal adenocarcinoma
fibronectin FNIII
PD-1
fibronectin type III repeat g
programmed cell death protein -1
gram 68Ga
PD-L1
gallium-68 GBM
programmed death-ligand 1
glioblastoma HAMA
PET
human-anti-mouse antibody HCAb
positron emission tomography
heavy-chain-only antibody HER2
Poly-ICLC
human epidermal growth factor receptor 2 HL
polyinosinic-polycytidylic acid
Hodgkin's lymphoma HLA
PR
human leucocyte antigen HLE-B3
partial response
human lens epithelial cells HNSCC
PTX
head and neck squamous cell carcinoma HSCT
paclitaxel
hematopoietic stem cell transplantation hTNC
RA
human TNC HUVEC
rheumatoid arthritis
human umbilical vein endothelial cells IC50
stable disease
inhibitory concentration 50 ID
SELEX
injected dose IF
systemic evolution of ligands by exponential enrichment
immunofluorescence IgG
SIP
immunoglobulin G IHC
small immunoprotein
immunohistochemistry 131I
siRNA
iodine-131 IL
short interfering RNA
interleukin IU
SLE
international unit Kd
systemic lupus erythematosus
equilibrium dissociation constant kDa
SSL
kilodalton KPS
nanoliposome
Karnofsky performance status KRAS
STAT
Kirsten rat sarcoma viral oncogene LNA
signal transducer and activator of transcription
locked nucleic acid 177Lu
TA
lutetium-177 mAb
tenascin assembly
monoclonal antibody mg
TGF
milligram ml
tumor growth factor
milliliter ng
TIL
nanogram MAREMO
tumor infiltrating leukocyte
matrix regulating motif MBS
TLR4
MAREMO binding site MFR
toll-like receptor 4
magnetic fluorescent radioisotope mRNA
t-Lyp-1
messenger RNA miRNA
microRNA MMTV-NeuNT
mouse mammary tumor virus-NeuNT MR
magnetic resonance MTD
maximum tolerated dose Nb
nanobody NB
nanobubbles NHL
non-Hodgkin lymphoma NK
natural killer cell nM
nanomolar 4NQO
4-Nitroquinoline 1-oxide NRP-1
neuropilin-1 NP
nanoparticle NSLC
non-small lung carcinomas NW
nanoworm OS
overall survival OSCC
oral squamous cell carcinoma PAGRIT
pretargeted antibody-guided radioimmunotherapy PC-3
prostate carcinoma cells PDAC
pancreatic ductal adenocarcinoma PD-1
programmed cell death protein -1 PD-L1
programmed death-ligand 1 PET
positron emission tomography Poly-ICLC
polyinosinic-polycytidylic acid PR
partial response PTX
paclitaxel RA
rheumatoid arthritis stable disease SELEX
systemic evolution of ligands by exponential enrichment SIP
small immunoprotein siRNA
short interfering RNA SLE
systemic lupus erythematosus SSL
nanoliposome STAT
signal transducer and activator of transcription TA
tenascin assembly TGF
tumor growth factor TIL
tumor infiltrating leukocyte TLR4
toll-like receptor 4 t-Lyp-1
anti-drug antibodies
ADCC
antibody-dependent cell mediated cytotoxicity
ADC
antibody-drug-conjugate
AgNPs
metallic silver nanoparticles
ApoE
apolipoprotein E
211At
astatine-211
AML
acute myeloid leukemia
BALB
bagg albino
CAF
carcinoma associated fibroblasts
CAIA
collagen antibody induced arthritis
CAR-T
chimeric antigen receptor-T cell
CCR
C-chemokine receptor
CCL21
chemokine ligand 21
CD
cluster differentiation
CDR
complementarity-determining regions
ch
chimeric
CPTD
camptothecin prodrug
CR
complete response
Cri
incomplete count recovery
64Cu
copper-64
CXCL
danger associated molecular pattern
DNA
deoxyribonucleic acid
DOTA
dodecane tetraacetic acid
DOX
doxorubicin
ECM
extracellular matrix
EDA
extra domain A
EGFL
epidermal growth factor-like repeats
EGFR
epidermal growth factor receptor
ELISA
enzyme-linked immunosorbent assay
EMT
epithelial mesenchymal transition
18F
fluorodeoxyglucose
Fab
fragment antigen-binding
FAM
fluorescein
FBG
fibrinogen like globular domain
Fc
fragment cristallin
FITC
Domaines
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