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Article Dans Une Revue Blood Transfusion Année : 2024

First investigation of RH gene polymorphism in patients with sickle cell disease and associated blood donors in Cameroon, Central Africa

Jeanne Manga
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Messina Mbeti
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Estelle Wete
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Hortense Ngegni Pangetha
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Simon Noël Ateba
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Jules Tchatchueng
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Alexandre Njan Nloga
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Jeanne Manga Messina
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Résumé

Although genetic polymorphism of the RH blood group system is well known in sub-Saharan Africa, national/regional specificities still remain to be described precisely. For the first time in Cameroon, Central Africa, and in order to better characterize the molecular basis driving RH phenotype variability, as well as to identify the main antigens that may be potentially responsible for alloimmunization, we sought 1) to study the RH genes in a cohort of 109 patients with sickle cell disease; 2) to study the same genes in the corresponding donors whose red blood cells (RBCs) were transfused to the patients (108 donors in 98 patients); 3) to predict RH phenotype on the basis of the molecular data and compare the results with serologic testing; and 4) to identify retrospectively patients at risk for alloimmunization.
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Dates et versions

hal-04503247 , version 1 (13-03-2024)

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Jeanne Manga, Messina Mbeti, Caroline Bénech, Françoise Ngo Sack, Estelle Wete, et al.. First investigation of RH gene polymorphism in patients with sickle cell disease and associated blood donors in Cameroon, Central Africa. Blood Transfusion, In press, ⟨10.2450/BloodTransfus.660⟩. ⟨hal-04503247⟩
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