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Journal Articles Vaccine Year : 2013

Priorities for research on meningococcal disease and the impact of serogroup A vaccination in the African meningitis belt

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Danny Altmann
  • Function : Author
Abraham Aseffa
  • Function : Author
Margaret Bash
  • Function : Author
Nicole Basta
  • Function : Author
Ray Borrow
  • Function : Author
Claire Broome
  • Function : Author
Dominique Caugant
  • Function : Author
Tom Clark
  • Function : Author
Mamoudou Djingarey
  • Function : Author
David Goldblatt
  • Function : Author
Ulla Griffiths
  • Function : Author
Rana Hajjeh
  • Function : Author
Musa Hassan-King
  • Function : Author
Stephane Hugonnet
  • Function : Author
Ann Marie Kimball
  • Function : Author
Marc Laforce
  • Function : Author
Calman Maclennan
  • Function : Author
Martin C J Maiden
  • Function : Author
Olivier Manigart
  • Function : Author
Leonard Mayer
  • Function : Author
Nancy Messonnier
  • Function : Author
Jennifer Moisi
  • Function : Author
Katie Moore
  • Function : Author
Daugla Doumagoum Moto
  • Function : Author
Maria Nascimento
  • Function : Author
Stephen Obaro
  • Function : Author
Rasmata Ouedraogo
  • Function : Author
Anne-Laure Page
  • Function : Author
Willima Perea
  • Function : Author
Gerd Pluschke
  • Function : Author
Mari-Pierre Preziosi
  • Function : Author
Samba Sow
  • Function : Author
David Stephens
  • Function : Author
James Stuart
  • Function : Author
Madeleiene Thomson
  • Function : Author
Sylvestre Tiendrebeogo
  • Function : Author
Jean-Francois Trape
  • Function : Author
Guy Vernet
  • Function : Author

Abstract

For over 100 years, large epidemics of meningococcal meningitis have occurred every few years in areas of the African Sahel and sub-Sahel known as the African meningitis belt. Until recently, the main approach to the control of these epidemics has been reactive vaccination with a polysaccharide vaccine after an outbreak has reached a defined threshold and provision of easy access to effective treatment but this approach has not prevented the occurrence of new epidemics. Meningococcal conjugate vaccines, which can prevent meningococcal carriage and thus interrupt transmission, may be more effective than polysaccharide vaccines at preventing epidemics. Because the majority of African epidemics have been caused by serogroup A meningococci, a serogroup A polysaccharide/tetanus toxoid protein conjugate vaccine (PsA-TT) has recently been developed. Results from an initial evaluation of the impact of this vaccine on meningococcal disease and meningococcal carriage in Burkina Faso have been encouraging. To review how the research agenda for meningococcal disease in Africa has been changed by the advent of PsA-TT and to define a new set of research priorities for study of meningococcal infection in Africa, a meeting of 41 scientists was held in Dakar, Senegal on April 24th and 25th 2012. The research recommendations developed during the course of this meeting are presented in this paper. The need for enhanced surveillance for meningitis in defined populations with good diagnostic facilities in African countries at risk of epidemics was identified as the highest priority. This is needed to determine the duration of protection against serogroup A meningococcal disease provided by PsA-TT and to determine the risk of disease and carriage caused by meningococci of other serogroups. Other research areas given high priority included identification and validation of serological correlates of protection against meningococcal disease and carriage, development of improved methods for detecting carriage and epidemiological studies aimed at determining the reasons underlying the peculiar epidemiology of meningococcal disease in the African meningitis belt. Minutes and working papers from the meeting are provided in supplementary tables and some of the presentations made at the meeting are available on the MenAfriCar consortium website (www.menafricar.org) and on the web site of the Centers for Disease Control (www.cdc.gov). Conference report - Dakar discussion group on priorities for research on epidemic meningococcal disease in Africa
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Dates and versions

hal-03034411 , version 1 (11-12-2020)

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Danny Altmann, Abraham Aseffa, Margaret Bash, Nicole Basta, Ray Borrow, et al.. Priorities for research on meningococcal disease and the impact of serogroup A vaccination in the African meningitis belt. Vaccine, 2013, 31 (11), pp.1453-1457. ⟨10.1016/j.vaccine.2012.12.035⟩. ⟨hal-03034411⟩
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