Priorities for research on meningococcal disease and the impact of serogroup A vaccination in the African meningitis belt - Département Méthodes quantitatives en santé publique Accéder directement au contenu
Article Dans Une Revue Vaccine Année : 2013

Priorities for research on meningococcal disease and the impact of serogroup A vaccination in the African meningitis belt

Danny Altmann
  • Fonction : Auteur
Abraham Aseffa
  • Fonction : Auteur
Margaret Bash
  • Fonction : Auteur
Nicole Basta
  • Fonction : Auteur
Ray Borrow
  • Fonction : Auteur
Claire Broome
  • Fonction : Auteur
Dominique Caugant
  • Fonction : Auteur
Tom Clark
  • Fonction : Auteur
Mamoudou Djingarey
  • Fonction : Auteur
David Goldblatt
  • Fonction : Auteur
Ulla Griffiths
  • Fonction : Auteur
Rana Hajjeh
  • Fonction : Auteur
Musa Hassan-King
  • Fonction : Auteur
Stephane Hugonnet
  • Fonction : Auteur
Ann Marie Kimball
  • Fonction : Auteur
Marc Laforce
  • Fonction : Auteur
Calman Maclennan
  • Fonction : Auteur
Martin C J Maiden
  • Fonction : Auteur
Olivier Manigart
  • Fonction : Auteur
Leonard Mayer
  • Fonction : Auteur
Nancy Messonnier
  • Fonction : Auteur
Jennifer Moisi
  • Fonction : Auteur
Katie Moore
  • Fonction : Auteur
Daugla Doumagoum Moto
  • Fonction : Auteur
Maria Nascimento
  • Fonction : Auteur
Stephen Obaro
  • Fonction : Auteur
Rasmata Ouedraogo
  • Fonction : Auteur
Anne-Laure Page
  • Fonction : Auteur
Willima Perea
  • Fonction : Auteur
Gerd Pluschke
  • Fonction : Auteur
Mari-Pierre Preziosi
  • Fonction : Auteur
Samba Sow
  • Fonction : Auteur
David Stephens
  • Fonction : Auteur
James Stuart
  • Fonction : Auteur
Madeleiene Thomson
  • Fonction : Auteur
Sylvestre Tiendrebeogo
  • Fonction : Auteur
Jean-Francois Trape
  • Fonction : Auteur
Guy Vernet
  • Fonction : Auteur

Résumé

For over 100 years, large epidemics of meningococcal meningitis have occurred every few years in areas of the African Sahel and sub-Sahel known as the African meningitis belt. Until recently, the main approach to the control of these epidemics has been reactive vaccination with a polysaccharide vaccine after an outbreak has reached a defined threshold and provision of easy access to effective treatment but this approach has not prevented the occurrence of new epidemics. Meningococcal conjugate vaccines, which can prevent meningococcal carriage and thus interrupt transmission, may be more effective than polysaccharide vaccines at preventing epidemics. Because the majority of African epidemics have been caused by serogroup A meningococci, a serogroup A polysaccharide/tetanus toxoid protein conjugate vaccine (PsA-TT) has recently been developed. Results from an initial evaluation of the impact of this vaccine on meningococcal disease and meningococcal carriage in Burkina Faso have been encouraging. To review how the research agenda for meningococcal disease in Africa has been changed by the advent of PsA-TT and to define a new set of research priorities for study of meningococcal infection in Africa, a meeting of 41 scientists was held in Dakar, Senegal on April 24th and 25th 2012. The research recommendations developed during the course of this meeting are presented in this paper. The need for enhanced surveillance for meningitis in defined populations with good diagnostic facilities in African countries at risk of epidemics was identified as the highest priority. This is needed to determine the duration of protection against serogroup A meningococcal disease provided by PsA-TT and to determine the risk of disease and carriage caused by meningococci of other serogroups. Other research areas given high priority included identification and validation of serological correlates of protection against meningococcal disease and carriage, development of improved methods for detecting carriage and epidemiological studies aimed at determining the reasons underlying the peculiar epidemiology of meningococcal disease in the African meningitis belt. Minutes and working papers from the meeting are provided in supplementary tables and some of the presentations made at the meeting are available on the MenAfriCar consortium website (www.menafricar.org) and on the web site of the Centers for Disease Control (www.cdc.gov). Conference report - Dakar discussion group on priorities for research on epidemic meningococcal disease in Africa
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Dates et versions

hal-03034411 , version 1 (11-12-2020)

Identifiants

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Danny Altmann, Abraham Aseffa, Margaret Bash, Nicole Basta, Ray Borrow, et al.. Priorities for research on meningococcal disease and the impact of serogroup A vaccination in the African meningitis belt. Vaccine, 2013, 31 (11), pp.1453-1457. ⟨10.1016/j.vaccine.2012.12.035⟩. ⟨hal-03034411⟩
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